|
Table 4.
Genes whose haploid deletion mutants show enhanced resistance to caspofungin
|
|
| ORF |
Gene |
Comment |
|
| Cell wall assembly |
| YGR032W |
FKS2 |
ß-1,3-Glucan synthase subunit |
| YOR008C |
SLG1 |
Sensor for the PKC1-SLT2 cell integrity pathway |
| YLR425W |
TUS1 |
GDP-GTP exchange factor for Rho1p |
| Cytoskeleton and vesicular transport |
| YDR093W |
DNF2 |
Putative flippase, aminophospholipid transporter |
| YNL323W |
LEM3 |
Required for plasma membrane translocation of phosphatidylcholine and phosphatidylethanolamine |
| YBR171W |
SEC66 |
Component of ER protein-translocation subcomplex |
| YBR105C |
VID24 |
Required for ubiquitin-regulated transport of Fbp1p into the vacuole by the cytoplasm to vacuole pathway |
| Stress and signal transduction |
| YOR197W |
MCA1 |
Cysteine protease of the metacaspase family |
| YDL079C |
MRK1 |
Member of the glycogen synthase kinase-3 family, involved in stress signaling |
| YJR153W |
PGU1 |
Endopolygalacturonase induced upon filamentation |
| YHR050W |
SMF2 |
Manganese transporter, mutant resistant to osmotic stress |
| YNR031C |
SSK2 |
MAPKK kinase involved in the high-osmolarity signal transduction pathway |
| Transcription and protein synthesis |
| YNL027C |
CRZ1 |
Calcineurin responsive zinc-finger transcription factor |
| YNL301C |
RPL18B |
Ribosomal protein |
| Other and unknown functions |
| YDR528W |
HLR1 |
Low similarity to Lre1p, a gene involved in the regulation of ß-1,3-glucan biosynthesis |
| YHR004C |
NEM1 |
Protein required for nuclear morphology |
| YJR033C |
RAV1 |
Regulator of the vacuolar H+-ATPase |
| YAR035W |
YAT1 |
Outer carnitine acetyltransferase |
| YCR087C-A |
|
Unknown function |
| YDR326C |
|
Protein with a GRAM domain, found on glucosyltransferases |
| YDR479C |
|
Peroxisomal integral membrane protein |
| YIL110W |
|
Repressed under stress conditions |
| YJR024C |
|
Enterobacterial L-ribose-5-phosphate 4-epimerases-like protein, possibly involved in carbohydrate metabolism |
| YLR338W |
|
Questionable ORF, overlaps with VRP1, a cortical actin patch component |
| YNL080C |
|
May play a role in respiratory growth |
| YOR024W |
|
Unknown function |
| YOR118W |
|
Unknown function |