| ||||||||||||||||||||||||||
Table 3. Two hundred and eleven candidate membrane-associated ubiquitinated proteins
|
Cytoskeleton/cell wall/cytokinesis |
||||
|
Gene |
TM domain |
Localization |
Description |
|
|
ECM21* |
No |
Unknown |
"ExtraCellular Mutant" protein of unknown function |
|
|
CHS3 |
Yes |
Plasma Membrane |
Chitin synthase III |
|
|
CHS2 |
Yes |
Plasma Membrane |
Chitin synthase II |
|
|
ECM33 |
Yes |
Plasma Membrane |
"ExtraCellular Mutant" protein of unknown function |
|
|
BUD3 |
Predicted |
Bud Neck Membrane |
Bud neck protein required for axial budding |
|
|
SPO71 |
Predicted |
Spore Wall |
Protein involved in spore wall formation |
|
|
SAC6 |
No |
Actin Cytoskeleton |
Actin filament bundling protein Fimbrin homolog |
|
|
NUM1 |
No |
Microtubule Cytoskeleton |
Tubulin-binding protein required for G2 nucleus migration |
|
|
RVS167 |
No |
Actin Cytoskeleton |
BAR adaptor protein; actin cytoskeleton regulator |
|
|
ACT1 |
No |
Actin Cytoskeleton |
Actin |
|
|
GSC2 |
Yes |
Plasma Membrane |
Beta-1,3-glucan synthase |
|
|
SKN1 |
Yes |
Golgi Membrane |
Beta-1,6-glucan synthase (putative) |
|
|
BGL2 |
No |
Cell Wall |
Cell wall endo-beta-1,3-glucanase |
|
|
RHO3 |
No |
Actin Cytoskeleton |
Ras homolog; GTP-binding actin cytoskeleton regulator |
|
|
BUD4 |
No |
Bud Neck (Peripheral) |
Bud neck protein required for axial budding |
|
|
FKS1* |
Yes |
Plasma Membrane |
Beta-1,3-glucan synthase |
|
|
YLR422W |
Predicted |
Unknown Membrane |
Protein of unknown function containing region of homology to mouse actin regulatory protein Dock2 |
|
|
GAS1 |
Yes |
Plasma Membrane |
1,3-Beta-Glucanosyltransferase |
|
|
CHS1 |
Yes |
Plasma Membrane |
Chitin synthase I |
|
|
HUA2 |
No |
Actin Cytoskeleton |
Putative role in assembly of cortical actin patches |
|
|
KRE6 |
Yes |
Golgi Membrane |
Beta-1,6-glucan synthase (putative) |
|
|
DNA Replication/Transcription |
||||
|
HTB2/HTB1* |
No |
Nucleus |
Histone H2B |
|
|
CDC47 |
No |
Nucleus |
MCM/P1 family member involved in DNA synthesis initiation |
|
|
RPO21* |
No |
Nucleus |
RNA polymerase II, largest subunit |
|
|
CDC1 |
Predicted |
Unknown Membrane |
Protein that affects bud emergence, intrachromosomal recombination, and nuclear division |
|
|
TRA1 |
No |
Nucleus |
Member SAGA histone acetyltransferase complex |
|
|
IMP2 |
Predicted |
Unknown Membrane |
Transcription factor encoded by YIL154C; Regulates mitochondrial sugar utilization |
|
|
MGA2 |
Yes |
ER-Nuclear Membrane |
ER-anchored OLE1 transcription factor |
|
|
RNR2 |
No |
Nucleus |
Ribonucleotide reductase (small subunit) |
|
|
SPT23 |
Yes |
ER-Nuclear Membrane |
ER-anchored OLE1 transcription factor |
|
|
MET4 |
No |
Nucleus |
Transcription factor; Regulates sulfur assimilation pathway |
|
|
RPB2 |
No |
Nucleus |
RNA polymerase II, second-largest subunit |
|
|
Lipid/Ergosterol Metabolism/Modification |
||||
|
TSC13 |
Predicted |
ER-Nuclear Membrane |
Very-long-chain fatty acid (VLCFA) metabolism |
|
|
LCB2 |
Yes |
ER-Nuclear Membrane |
Component of serine C-palmitoyltransferase; Sphingolipid biosynthesis |
|
|
DPL1 |
Predicted |
ER-Nuclear Membrane |
Dihydrosphingosine-1-phosphate lyase; Sphingolipid metabolism |
|
|
SUR2 |
Yes |
ER-Nuclear Membrane |
Sphingosine hydroxylase; Sphingolipid metabolism |
|
|
SCS2 |
Yes |
ER-Nuclear Membrane |
Involved in regulation of INO1 expression |
|
|
SCS3 |
Predicted |
Unknown Membrane |
Involved in inositol phospholipid biosynthesis |
|
|
ERG25* |
Yes |
ER-Nuclear Membrane/Plasma Membrane |
C-4 sterol methyl oxidase; Ergosterol biosynthesis |
|
|
ERG1* |
Yes |
ER-Nuclear Membrane |
Squalene monooxygenase; Ergosterol biosynthesis |
|
|
ERG11 |
Predicted |
ER-Nuclear Membrane |
Cytochrome P450, lanosterol 14a-demethylase; Ergosterol biosynthesis |
|
|
NCP1* |
Yes |
ER-Nuclear Membrane |
NADP-cytochrome P450 reductase |
|
|
ERG9 |
Yes |
ER-Nuclear Membrane |
Squalene synthetase; Ergosterol biosynthesis |
|
|
INP51 |
Predicted |
Unknown Membrane |
Inositol polyphosphate-5-phosphatase |
|
|
CBR1 |
Predicted |
ER-Nuclear Membrane |
NADH-cytochrome b5 reductase |
|
|
TES1 |
Predicted |
Peroxisomal Membrane |
Acyl-CoA thioesterase; Fatty-acid oxidation |
|
|
TOR2 |
No |
Plasma Membrane/Vacuolar Membrane (Peripheral) |
Putative phosphatidylinositol kinase involved in actin cytoskeleton, translation, and meiosis |
|
|
SAC1 |
Yes |
ER-Nuclear Membrane |
Polyphosphoinositide phosphatase |
|
|
YLL012W |
Predicted |
Unknown Membrane |
Putative phosphatidylinositol-binding protein |
|
|
ERG27 |
Predicted |
ER-Nuclear Membrane |
3-Keto sterol reductase; Ergosterol biosynthesis |
|
|
STT4 |
No |
Plasma Membrane |
Phosphatidylinositol-4-kinase |
|
|
YML125C |
Predicted |
Unknown Membrane |
Protein with similarity to NADH-cytochrome b5 reductase |
|
|
ERG5 |
Predicted |
ER-Nuclear Membrane |
Cytochrome P450, delta 22(23) sterol desaturase; Ergosterol biosynthesis |
|
|
ERG2 |
Predicted |
ER-Nuclear Membrane |
Sterol C8-C7 isomerase; Ergosterol biosynthesis |
|
|
SCS7 |
Predicted |
ER-Nuclear Membrane |
Ceramide hydroxylase; Very long chain fatty acid (VLCFA) metabolism |
|
|
LCB1 |
Yes |
ER-Nuclear Membrane |
Component of serine C-palmitoyltransferase; Sphingolipid biosynthesis |
|
|
Membrane transporter/permease/pump |
||||
|
Gene |
TM Domain |
Localization |
Description |
|
|
TAT1* |
Yes |
Plasma Membrane |
Plasma membrane valine, leucine, isoleucine, and tyrosine transporter |
|
|
PHO88 |
Predicted |
Unknown Membrane |
Involved in inorganic phosphate transport |
|
|
SNQ2 |
Yes |
Plasma Membrane |
Plasma membrane drug-efflux pump |
|
|
ENA5/ENA2/ENA1* |
Yes |
Plasma Membrane |
Plasma membrane sodium pump |
|
|
BAP3 |
Yes |
Plasma Membrane |
Plasma membrane branched-chain amino acid permease |
|
|
DNF2 |
Yes |
Plasma Membrane |
Plasma membrane putative phospholipid transporter; "Flipase" |
|
|
YDR119W |
Predicted |
Unknown Membrane |
Putative multidrug resistance transporter |
|
|
YCF1 |
Yes |
Vacuolar Membrane |
Vacuolar glutathione-conjugate transporter |
|
|
HXT7 |
Yes |
Plasma Membrane |
Plasma membrane high-affinity hexose transporter |
|
|
HXT3 |
Yes |
Plasma Membrane |
Plasma membrane low-affinity hexose transporter |
|
|
ITR1* |
Yes |
Plasma Membrane |
Plasma membrane myo-inositol permease |
|
|
GNP1 |
Yes |
Plasma Membrane |
Plasma membrane glutamine permease |
|
|
NPR2 |
Predicted |
Unknown Membrane |
Putative nitrogen permease regulator |
|
|
PMC1 |
Yes |
Vacuolar Membrane |
Vacuolar calcium transporter |
|
|
PMA1* |
Yes |
Plasma Membrane |
Plasma membrane proton pump |
|
|
HIP1 |
Yes |
Plasma Membrane |
Plasma membrane histidine permease |
|
|
TNA1 |
Yes |
Plasma Membrane |
Plasma membrane nicotinic acid transporter |
|
|
YOR1 |
Yes |
Plasma Membrane |
Plasma membrane multispecific organic anion transporter |
|
|
YHR032W |
Predicted |
Unknown Membrane |
Putative membrane transporter |
|
|
HXT4* |
Yes |
Plasma Membrane |
Plasma membrane moderate- to low-affinity hexose transporter |
|
|
NEO1 |
Predicted |
Unknown Membrane |
Putative phospholipid transporter ; "Flipase" |
|
|
YJR015W |
Predicted |
Unknown Membrane |
Potential multidrug resistance transporter |
|
|
STE6 |
Yes |
Plasma Membrane |
Plasma membrane mating pheromone transporter |
|
|
GAP1* |
Yes |
Plasma Membrane |
Plasma membrane general amino acid permease |
|
|
PTR2 |
Yes |
Plasma Membrane |
Plasma membrane peptide permease |
|
|
BPT1 |
Yes |
Vacuolar Membrane |
Vacuolar glutathione-conjugate transporter |
|
|
YBT1 |
Yes |
Vacuolar Membrane |
Vacuolar bile acid transporter |
|
|
CCC1 |
Yes |
Vacuolar Membrane |
Vacuolar calcium/manganese/iron transporter |
|
|
PHO84 |
Yes |
Plasma Membrane |
Plasma membrane high-affinity inorganic phosphate transporter |
|
|
HXT2 |
Yes |
Plasma Membrane |
Plasma membrane high-affinity hexose transporter |
|
|
YMR166C |
Yes |
Mitochondrial Membrane |
Putative mitochondrial inner membrane transporter |
|
|
RSN1 |
Predicted |
Unknown Membrane |
Possible membrane transporter |
|
|
LYP1 |
Yes |
Plasma Membrane |
Plasma membrane high affinity lysine permease |
|
|
SMF1 |
Yes |
Plasma Membrane |
Plasma membrane manganese transporter |
|
|
PDR5* |
Yes |
Plasma Membrane |
Plasma membrane multidrug resistance transporter |
|
|
TPO4 |
Yes |
Plasma Membrane/Vacuolar Membrane |
Plasma membrane polyamine transporter |
|
|
PMA2* |
Yes |
Plasma Membrane |
Plasma membrane proton pump |
|
|
PDR12 |
Yes |
Plasma Membrane |
Plasma membrane multidrug resistance transporter |
|
|
DIP5 |
Yes |
Plasma Membrane |
Plasma membrane dicarboxylic amino acid permease |
|
|
VMA13 |
No |
Vacuolar Membrane (Peripheral) |
Regulatory subunit of vacuolar proton pump (V-ATPase) |
|
|
Protein glycosylation and lipid modification |
||||
|
PMT2 |
Predicted |
ER-Nuclear Membrane |
Mannosyltransferase responsible for initiation of O-linked glycosylation |
|
|
WBP1 |
Yes |
ER-Nuclear Membrane |
Beta-subunit of oligosaccharyltransferase involved in N-linked glycosylation |
|
|
GPI16 |
Yes |
ER-Nuclear Membrane |
Subunit of GPI transamidase |
|
|
PMT4 |
Predicted |
ER-Nuclear Membrane |
Mannosyltransferase responsible for initiation of O-linked glycosylation |
|
|
ALG9 |
Predicted |
ER-Nuclear Membrane |
Mannosyltransferase involved in N-linked glycosylation |
|
|
ECM39 |
Predicted |
ER-Nuclear Membrane |
Alpha-1,6-mannosyltransferase involved in N-linked glycosylation |
|
|
OST3 |
Yes |
ER-Nuclear Membrane |
Gamma-subunit of oligosaccharyltransferase involved in N-linked glycosylation |
|
|
KTR1 |
Yes |
Golgi Membrane |
Alpha-1,2-mannosyltransferase involved in N- and O-linked glycosylation |
|
|
DPM1 |
Predicted |
ER-Nuclear Membrane |
Dolichol-phosphate mannosyltransferase involved in N- and O-linked glycosylation; GPI anchor biosynthesis |
|
|
Protein Synthesis/Folding/Translocation |
||||
|
Gene |
TM Domain |
Localization |
Description |
|
|
SSA1 |
No |
Cytoplasm/Ribosome/Vacuolar Membrane (Peripheral) |
Cytoplasmic chaperone and heat shock protein |
|
|
PTH2* |
No |
Cytoplasm |
Aminoacyl-tRNA hydrolase |
|
|
RPL23A/RPL23B |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Large subunit ribosomal protein L23 |
|
|
TEF2/TEF1 |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Ribosome-associated translation elongation factor EF-1 alpha |
|
|
SSH1 |
Yes |
ER-Nuclear Membrane |
SEC61 homolog involved in co-translational pathway of protein transport |
|
|
PDI1 |
No |
ER Lumen |
ER lumenal protein disulfide isomerase and oxidoreductase |
|
|
MRH1 |
Yes |
Plasma Membrane |
Plasma membrane protein related to the Hsp30p chaperone and heat shock protein |
|
|
EFT2/EFT1 |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Ribosome-associated translation elongation factor EF-2 |
|
|
RPS18A/RPS18B |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Small subunit ribosomal protein S18 |
|
|
PAB1 |
No |
Nucleus/Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Poly(A)-binding protein |
|
|
RPL1B/RPL1A |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Large subunit ribosomal protein L1 |
|
|
GCN1 |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Translational activator of GCN4 in response to starvation |
|
|
RPS20* |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Small subunit ribosomal protein S20 |
|
|
SEC11 |
Yes |
ER-Nuclear Membrane |
Signal sequence processing protein |
|
|
KAR2 |
No |
ER Lumen |
ER lumenal heat shock protein required for protein translocation and nuclear fusion |
|
|
SSA2 |
No |
Cytoplasm/Ribosome/Vacuolar Membrane (Peripheral) |
Cytoplasmic chaperone and heat shock protein |
|
|
ERO1 |
No |
ER-Nuclear Membrane (Lumenal Peripheral) |
FAD-dependent oxidase of protein disulfide isomerase |
|
|
SIS1 |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Protein chaperone required for initiation of translation |
|
|
RPL3 |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Large subunit ribosomal protein L3 |
|
|
RPS7A |
No |
Cytoplasm/Ribosome/ER-Nuclear Membrane (Peripheral) |
Small subunit ribosomal protein S7 |
|
|
HSP82 |
No |
Cytoplasm |
Cytoplasmic chaperone and heat shock protein |
|
|
Ubiquitin/Proteasome Pathway |
||||
|
Gene |
TM Domain |
Localization |
Description |
|
|
Ubiquitin* |
No |
n/a |
Ubiquitin |
|
|
CDC48 |
No |
Cytoplasm/Nucleus/ER-Nuclear Membrane (Peripheral) |
AAA-ATPase required for ER-associated degradation, membrane fusion, and cell cycle progression |
|
|
UFD2 |
Predicted |
Unknown Membrane |
Ubiquitin conjugating factor E4; Required for the assembly of multi-ubiquitin chains |
|
|
TOM1 |
Predicted |
Unknown Membrane |
Protein required for the G2/M transition, has similarity to Rsp5p, a HECT-domain ubiquitin-protein ligase (E3 enzyme) |
|
|
RPN3 |
No |
Proteasome/ER-Nuclear Membrane (Peripheral)/Nucleus |
Non-ATPase component of 26S proteasome complex, also functions in RNA polymerase II transcription elongation |
|
|
PUP3 |
No |
Proteasome/ER-Nuclear Membrane (Peripheral)/Nucleus |
20S proteasome subunit beta3_sc |
|
|
UBC6 |
Yes |
ER-Nuclear Membrane |
Ubiquitin-conjugating enzyme, anchored in the ER membrane with the catalytically active domain in cytoplasm |
|
|
RSP5 |
No |
Plasma Membrane/ER-Nuclear Membrane (Peripheral) |
Essential HECT-domain ubiquitin-protein ligase (E3 enzyme) |
|
|
DDI1* |
No |
Plasma Membrane (Peripheral) |
Protein involved in ubiquitin-dependent protein degradation, binds to t- and v-SNARE complexes |
|
|
PRE9* |
No |
Proteasome/ER-Nuclear Membrane (Peripheral)/Nucleus |
20S proteasome subunit alpha3_sc |
|
|
UBR1 |
Predicted |
Unknown Membrane |
Ubiquitin-protein ligase (N-recognin or E3 enzyme), involved in selection of substrates for the N-end rule pathway |
|
|
RPN1 |
No |
Proteasome/ER-Nuclear Membrane (Peripheral)/Nucleus |
Non-ATPase component of the 26S proteasome complex, also functions in RNA polymerase II transcription elongation |
|
|
SSM4 |
Yes |
ER-Nuclear Membrane |
E3 ubiquitin ligase of the endoplasmic reticulum |
|
|
HRD3 |
Yes |
ER-Nuclear Membrane |
ER-membrane protein required for ER-associated degradation |
|
|
CUE1 |
Yes |
ER-Nuclear Membrane |
ER-membrane protein required for ER-associated degradation (through ER-recruitment of the E2 ubiquitin conjugating enzyme) |
|
|
CUE5 |
Predicted |
Unknown Membrane |
Member of the CUE domain family, which bind ubiquitin-conjugating enzymes |
|
|
Vesicle Transport/Protein Trafficking |
||||
|
YAL048C |
Predicted |
Unknown Membrane |
Protein of unknown function involved in the secretory pathway |
|
|
ERP1 |
Yes |
Transport Vesicle Membrane |
Component of COPII-coated vesicles |
|
|
COP1 |
No |
Transport Vesicle Membrane (Peripheral) |
Coatomer (COPI) complex alpha chain of secretory pathway vesicles required for retrograde Golgi to ER transport |
|
|
GSG1 |
No |
Transport Vesicle Membrane (Peripheral) |
TRAPP-complex protein involved in vesicular transport from the ER to the Golgi and Golgi trafficking |
|
|
SEC27 |
No |
Transport Vesicle Membrane (Peripheral) |
Coatomer (COPI) complex beta' chain of secretory pathway vesicles, required for retrograde Golgi to ER transport |
|
|
EMP24 |
Yes |
Transport Vesicle Membrane |
Component of COPII-coated vesicles possibly involved in cargo sorting |
|
|
GGA2 |
No |
Golgi Membrane (Peripheral) |
Protein involved in trafficking of proteins between the trans-Golgi network and the vacuole |
|
|
GVP36 |
No |
Transport Vesicle Membrane (Peripheral) |
Putative Golgi-vesicle protein |
|
|
YKT6 |
Yes |
Transport Vesicle Membrane |
Synaptobrevin (v-SNARE) homolog essential for ER-Golgi transport |
|
|
VPS13 |
No |
Transport Vesicle Membrane (Peripheral) |
Protein involved in vacuolar sorting |
|
|
SEL1 |
Predicted |
Unknown Membrane |
Protein involved in secretory pathway |
|
|
GSF2 |
Yes |
ER-Nuclear Membrane |
Protein required for secretion of Hxt1p glucose transporter |
|
|
SSO2 |
Yes |
Transport Vesicle Membrane |
Syntaxin homolog (t-SNARE) involved in vesicle transport from Golgi to plasma membrane |
|
|
VTI1 |
Yes |
Transport Vesicle Membrane |
Synaptobrevin (v-SNARE) homolog required for cis-Golgi trafficking and involved in Golgi to prevacuole trafficking |
|
|
CVT19 |
No |
Perivacuolar Preautophagosomal Structure |
Protein involved in cytoplasm to vacuole targeting (CVT) pathway |
|
|
YOR086C |
Predicted |
Unknown Membrane |
C2-domain containing protein homologous to mouse synaptotagmin 7, which is involved in synaptic vesicle fusion |
|
|
NCE102 |
Yes |
ER-Nuclear Membrane |
Involved in secretion of proteins that lack classical secretory signal sequences |
|
|
Other |
||||
|
GDH3 |
No |
Cytoplasm |
Glutamate dehydrogenase (NADP+); Glutamate biosynthesis |
|
|
IRA1 |
Yes |
Plasma Membrane |
Plasma membrane Ras GTPase activator (GAP) |
|
|
FZO1 |
Yes |
Mitochondrial Membrane |
Transmembrane GTPase required for mitochondrial fusion and maintenance of mitochondrial DNA |
|
|
RNQ1 |
No |
Cytoplasm |
[RNQ+] prion |
|
|
NUP84 |
No |
NPC/ER-Nuclear Membrane (Peripheral) |
Nuclear pore complex subunit |
|
|
GLY1* |
No |
Cytoplasm |
Threonine aldolase; Glycine biosynthesis |
|
|
STE2 |
Yes |
Plasma Membrane |
Plasma membrane alpha-factor pheromone receptor |
|
|
YFR006W* |
Predicted |
Unknown Membrane |
Putative Xaa-Pro aminopeptidase |
|
|
NUP145 |
No |
NPC/ER-Nuclear Membrane (Peripheral) |
Nuclear pore complex subunit |
|
|
LSB1* |
No |
Cytoplasm |
LAs17 Binding protein; Contains SH3 domain |
|
|
ENO2 |
No |
Cytoplasm |
Enolase 2; Glycolysis |
|
|
VTC4 |
Yes |
Vacuolar Membrane |
Subunit of VTC complex required for vacuolar membrane fusion, involved in vacuolar polyphosphate accumulation |
|
|
CPS1 |
Yes |
Vacuolar Membrane |
Vacuolar carboxypeptidase yscS |
|
|
STE24 |
Yes |
ER-Nuclear Membrane |
ER-localized zinc-metalloprotease that processes a-factor pheromone |
|
|
PSR2 |
No |
Plasma Membrane (Peripheral) |
Plasma membrane associated phosphatase required for sodium stress response |
|
|
PDC1 |
No |
Cytoplasm |
Pyruvate decarboxylase isozyme 1; Ethanol fermentation, pyruvate metabolism |
|
|
FRE1 |
Yes |
Plasma Membrane |
Ferric (and cupric) reductase; Facilitates iron uptake |
|
|
ALO1 |
Predicted |
Mitochondrial Membrane |
D-arabinino-1,4-lactone oxidase; D-erythroascorbic acid biosynthesis |
|
|
MKT1 |
Predicted |
Unknown Membrane |
Protein involved in propagation of M2 dsRNA satellite of L-A virus |
|
|
AAH1 |
No |
Cytoplasm |
Adenine deaminase; Adenine catabolism |
|
|
ASI2 |
Predicted |
Unknown Membrane |
Involved in regulation of amino acid permease gene expression |
|
|
MAM3 |
Predicted |
Unknown Membrane |
Hemolysin-like protein required for normal mitochondrial structure |
|
|
YOR256C |
Predicted |
Plasma Membrane |
Putative plasma membrane protein with similarity to human NAALAD2, which is a glutamate carboxypeptidase |
|
|
GDH1 |
No |
Cytoplasm |
Glutamate dehydrogenase (NADP+); Glutamate biosynthesis |
|
|
GLN1* |
No |
Cytoplasm |
Glutamine synthetase; Glutamine biosynthesis |
|
|
Unknown |
||||
|
YAR028W* |
Predicted |
ER-Nuclear Membrane |
Members of duplicated family of subtelomerically encoded COS proteins of unknown function |
|
|
YBR005W |
Predicted |
Mitochondrial Membrane |
Putative mitochondrial protein of unknown function |
|
|
AKL1 |
Predicted |
Unknown Membrane |
Serine/threonine protein kinase of unknown function |
|
|
COS2* (+others) |
Predicted |
ER-Nuclear membrane |
Member of duplicated family of subtelomerically encoded COS proteins of unknown function |
|
|
SNA4 |
Yes |
Vacuolar Membrane |
Vacuolar membrane protein of unknown function |
|
|
YRF1-1 (+others) |
Predicted |
Unknown Membrane |
Duplicated family of subtelomerically encoded YRF proteins of unknown function |
|
|
WWM1 |
Predicted |
Unknown Membrane |
Protein of unknown function; Interacts with metacaspase (Mca1p) |
|
|
YGR130C |
No |
Cytoplasm |
Protein of unknown function |
|
|
YHL010C* |
Predicted |
Unknown Membrane |
Protein of unknown function; Displays NLS binding activity |
|
|
YHR131C |
No |
Unknown |
PH-domain containing protein of unknown function |
|
|
YIL108W |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
YJL084C |
No |
Cytoplasm |
Arrestin(S-antigen)-domain containing protein of unknown function |
|
|
SNA3* |
Yes |
Vacuolar Membrane |
Vacuolar membrane protein of unknown function |
|
|
YJR088C |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
JSN1 |
Predicted |
Unknown Membrane |
PUF(mRNA binding)-domain containing protein of unknown function |
|
|
YET1* |
Yes |
ER-Nuclear Membrane |
ER membrane protein of unknown function |
|
|
YKL100C |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
SSH4 |
Predicted |
Unknown Membrane |
Protein of unknown function; Confers resistance to leflunomide upon overproduction |
|
|
YKR021W |
No |
Cytoplasm |
Arrestin(S-antigen)-domain containing protein of unknown function |
|
|
YLR413W |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
YLR414C* |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
USA1 |
Predicted |
Unknown Membrane |
Protein of unknown function; Interacts with the mRNA splicing factor Snp1p |
|
|
YML072C |
Predicted |
Unknown Membrane |
C2-domain containing protein of unknown function |
|
|
YMR160W |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
YMR209C |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
YNL058C |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
|
YOR164C |
No |
Cytoplasm |
Protein of unknown function |
|
|
YOR322C* |
Predicted |
Unknown Membrane |
Protein of unknown function |
|
TM, transmembrane; ER, endoplasmic reticulum.
*Indicates identified ubiquitination site. Shading indicates candidate ER-associated degradation (ERAD) substrates.
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